Article

<i>De novo</i> design of stable proteins that efficaciously inhibit oncogenic G proteins

2023-03-28

Abstract excerpt

Many protein therapeutics are competitive inhibitors that function by binding to endogenous proteins and preventing them from interacting with native partners. One effective strategy for engineering competitive inhibitors is to graft structural motifs from a native partner into a host protein. Here, we develop and experimentally test a computational protocol for embedding binding motifs in de novo designed protein...

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Identifiers and source

Literature Corpus work: e1a2980e-1e8b-59d8-8c7e-34f9f3bf87a2
DOI: 10.1101/2023.03.28.534629

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