Article

<i>De Novo</i> Design of Miniprotein Inhibitors of Bacterial Adhesins

2025-08-18

Abstract excerpt

The rise of multidrug-resistant bacterial infections necessitates the discovery of novel antimicrobial strategies. Here, we show that protein design provides a generalizable means of generating new antimicrobials by neutralizing the function of bacterial adhesins, which are virulence factors critical in host-pathogen interactions. We de novo designed high-affinity miniprotein binders to FimH and Abp1D/Abp2D chape...

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Literature Corpus work: b0b282a8-23a9-5646-b2a4-5d652111481f
DOI: 10.1101/2025.08.18.670751

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