Article

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

2025-06-01

Abstract excerpt

The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10 and the CCL28-specific receptor, CCR3. In this study, we conducted structure-function studies focused on the N-termini of these two chemokines to identify determinants of receptor activation, internalization and binding specificity. Deletion o...

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Literature Corpus work: 2253f277-f2f1-5049-b70e-ee2ae739c0b0
DOI: 10.1101/2025.05.27.656466

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