Article

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

2023-11-17

Abstract excerpt

By driving monocyte chemotaxis, the chemokine receptor CCR2 shapes inflammatory responses and the formation of tumor microenvironments. This makes it a promising target in inflammation and immuno-oncology; however, despite extensive efforts, there are no FDA-approved CCR2-targeting therapeutics. Cited challenges include the redundancy of the chemokine system, suboptimal properties of compound candidates, and speci...

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Literature Corpus work: 2c9da849-9819-5903-ac87-cb88ad6a20b7
DOI: 10.1101/2023.11.15.567150

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