Article

Analytical methodology for unveiling the physical effect of detergents on the function of full-length membrane proteins using a single-molecule tracking system

2026-07-30

Abstract excerpt

G protein-coupled receptors (GPCRs) are important targets for drug discovery because they are the largest and most diverse family of membrane proteins in the human body. As exemplified by β 2 -adrenergic receptor (β 2 AR), which is a typical class-A GPCRs, they are prone to denaturation and inactivation after solubilization. Although diverse techniques have been developed, current structural and functional analy...

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Literature Corpus work: c782cd9e-db84-50a6-bca1-0787e8402824
DOI: 10.64898/2026.07.27.740883

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