Article

The bigger picture: global analysis of solubilization performance of classical detergents versus new synthetic polymers utilizing shotgun proteomics

2023-07-11

Abstract excerpt

Integral membrane proteins are critical for many cellular functions. Roughly 25% of all human genes code for membrane proteins, and about 70% of all approved drugs target them. Despite their importance, laborious and harsh purification conditions often hinder their characterization. Traditionally, they are removed from the membrane using detergents, thereby taking the proteins out of their native environment, affe...

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Literature Corpus work: de992247-1566-5120-826d-5f3f8250e1ec
DOI: 10.1101/2023.07.11.548597

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