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Article

A crystal clear solution for determining G-protein-coupled receptor structures.

Trends in biochemical sciences - 1 Sept 2012

Tate Christopher G

Abstract excerpt

G-protein-coupled receptors (GPCRs) are medically important membrane proteins that are targeted by over 30% of small molecule drugs. At the time of writing, 15 unique GPCR structures have been determined, with 77 structures deposited in the PDB database, which offers new opportunities for drug development and for understanding the molecular mechanisms of GPCR activation. Many different factors have contributed to...

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PMID: 22784935
DOI: 10.1016/j.tibs.2012.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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