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Article

Analysis of Interactions between the Epidermal Growth Factor Receptor and Soluble Ligands on the Basis of Single-Molecule Diffusivity in the Membrane of Living Cells.

Angewandte Chemie (International ed. in English) - 8 Jun 2015

Kim Do-Hyeon, Zhou Kai, Kim Dong-Kyun, Park Soyeon, Noh Jungeun, Kwon Yonghoon, Kim Dayea, Song Nam Woong, Lee Jong-Bong, Suh Pann-Ghill, Lee Nam Ki, Ryu Sung Ho

Abstract excerpt

We present a single-molecule diffusional-mobility-shift assay (smDIMSA) for analyzing the interactions between membrane and water-soluble proteins in the crowded membrane of living cells. We found that ligand-receptor interactions decreased the diffusional mobility of ErbB receptors and β-adrener...

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PMID: 25940988
DOI: 10.1002/anie.201500871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25940988-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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