Article

Sub-millisecond conformational dynamics of the A <sub>2A</sub> adenosine receptor revealed by single-molecule FRET

2020-11-26

Abstract excerpt

The complex pharmacology of G-protein-coupled receptors (GPCRs) is defined by their multi-state conformational dynamics. Single-molecule Förster Resonance Energy Transfer (smFRET) is well-suited to quantify dynamics for individual protein molecules, however, its application to GPCRs is challenging; therefore, smFRET has been limited to studies of interreceptor interactions in cellular membranes and receptors in de...

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Literature Corpus work: 584eff38-12e6-5530-ba7f-50843b2fa7b3
DOI: 10.1101/2020.11.26.400184

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