Article

Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methods

2024-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Many physiological processes are dependent on G protein-coupled receptors (GPCRs), the biggest family of human membrane proteins and a significant class of therapeutic targets. Once activated by external stimuli, GPCRs use G proteins and arrestins as transducers to generate second messengers and trigger downstream signaling, leading to diverse signaling profiles. The G protein-coupled bile acid...

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Literature Corpus work: e119ab9c-526a-59e9-8e47-6d248879e2df
DOI: 10.1101/2024.10.21.619395

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