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Metabolic flux signatures of the ER unfolded protein response <i>in vivo</i> reveal decreased hepatic <i>de novo</i> lipogenesis and mobilization of lipids from adipose tissue to liver

2020-10-29

Abstract excerpt

The unfolded protein response in the endoplasmic reticulum (UPR ER ) is involved in a number of metabolic diseases, including non-alcoholic fatty liver disease. Here, we characterize the UPR ER induced metabolic changes in mouse liver through in vivo metabolic labeling and mass spectrometric analysis of proteome and lipid fluxes. We induced ER stress in vivo via tunicamycin treatment and measured rates of prot...

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Literature Corpus work
0a60b0b4-963f-56f4-9de3-3a1adb7bc9a9
DOI
10.1101/2020.10.29.360073
Open publication

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Metabolic flux signatures of the ER unfolded protein response <i>in vivo</i> reveal decreased hepatic <i>de novo</i> lipogenesis and mobilization of lipids from adipose tissue to liverDOI 10.1101/2020.10.29.360073
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