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Article

Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish.

Hepatology (Baltimore, Md.) - 1 Aug 2011

Cinaroglu Ayca, Gao Chuan, Imrie Dru, Sadler Kirsten C

Abstract excerpt

UNLABELLED: Many etiologies of fatty liver disease (FLD) are associated with the hyperactivation of one of the three pathways composing the unfolded protein response (UPR), which is a harbinger of endoplasmic reticulum (ER) stress. The UPR is mediated by pathways initiated by PRKR-like endoplasmic reticulum kinase, inositol-requiring 1A/X box binding protein 1, and activating transcription factor 6 (ATF6), and...

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Source

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Identifiers

PMID: 21538441
DOI: 10.1002/hep.24396
PMCID: PMC3145024

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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