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XBP-1 Remodels Lipid Metabolism to Extend Longevity

1 Jul 2019

Abstract excerpt

The endoplasmic reticulum unfolded protein response (UPR ER ) is a cellular stress response that maintains homeostasis within the secretory pathway, regulates glucose and lipid metabolism, and influences longevity. To ask whether this role in lifespan determination depends upon metabolic intermediaries, we metabotyped C. elegans expressing the active form of the UPR ER transcription factor XBP-1, XBP-1s, and...

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Share to Endoplasmic Reticulum Stress and Disease
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 31315038
DOI: 10.1016/j.celrep.2019.06.057

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