Article
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.
Hepatology (Baltimore, Md.) - 1 Aug 2011
Thakur Prakash C, Stuckenholz Carsten, Rivera Marcus R, Davison Jon M, Yao Jeffrey K, Amsterdam Adam, Sadler Kirsten C, Bahary Nathan
Abstract excerpt
UNLABELLED: Hepatic steatosis is the initial stage of nonalcoholic fatty liver disease (NAFLD) and may predispose to more severe hepatic disease, including hepatocellular carcinoma. Endoplasmic reticulum (ER) stress has been recently implicated as a novel mechanism that may lead to NAFLD, although the genetic factors invoking ER stress are largely unknown. During a screen for liver defects from a zebrafish...
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