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Article

Multi-functional role of apolipoprotein E in neurodegenerative diseases

29 Jan 2025

Abstract excerpt

Genetic diversity in the apolipoprotein E (ApoE) gene has been identified as the major susceptibility genetic risk factor for sporadic Alzheimer’s disease (SAD). Specifically, the ApoEε4 allele is a significant risk factor for SAD, while ApoEε2 allele provides protection compared to the more common ApoEε3 allele. This review discusses the role of the ApoE in AD and other neurodegenerative disorders. ApoE, a...

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Identifiers

PMID: 39944166
DOI: 10.3389/fnagi.2025.1535280

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