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Article

MicroRNA let-7: Regulation, single nucleotide polymorphism, and therapy in lung cancer.

Journal of cancer research and therapeutics - 1 Aug 2015

Yang Guang, Zhang Wenqi, Yu Chunlei, Ren Jin, An Zhe

Abstract excerpt

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) are highly evolutionarily conserved noncoding small RNAs, which were first identified in Caenorhabditis elegans. There are 1100 or more miRNAs have been identified in Homo sapiens. Let-7 miRNA is involved in the regulation of gene expression in cells. Several novel factors and feedback loops involved in the regulation of...

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PMID: 26323902
DOI: 10.4103/0973-1482.163830

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