Article

LINE-2 transposable elements are a source for functional human microRNAs and target sites

2017-11-13

Abstract excerpt

Transposable elements (TEs) are dynamically expressed at high levels in multiple human tissues, but the function of TE-derived transcripts remains largely unknown. In this study, we identify numerous TE-derived microRNAs (miRNAs) by conducting Argonaute2 RNA Immunoprecipitation followed by small RNA sequencing (AGO2 RIP-seq) on human brain tissue. Many of these miRNAs originated from LINE-2 (L2) elements, which en...

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Literature Corpus work: d222cd94-c3db-5cee-83bb-f619e8b59512
DOI: 10.1101/218842

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