Article

The Phosphate-Specific Transport System Gene <i>pstA1</i> Contributes to Rifampin Tolerance in <i>Mycobacterium tuberculosis</i>

2025-11-01

Abstract excerpt

Tuberculosis (TB) caused an estimated 10.8 million new cases and 1.25 million deaths in 2023. Antibiotic tolerance, the ability of bacteria to survive exposure to bactericidal antibiotics without genetic resistance mutations, contributes to the need for prolonged treatment. Targeting antibiotic tolerance mechanisms could promote accelerated clearance of Mycobacterium tuberculosis ( Mtb ), thereby improving medic...

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Literature Corpus work: 8cf0b768-7458-5afa-bc14-966010e4c7c5
DOI: 10.1101/2025.10.31.685634

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