Article

TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapy

2023-04-25

Abstract excerpt

<title>Abstract</title> The ability of <italic>Mycobacterium tuberculosis</italic> (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-sensing TCS that controls a functionally diverse 117-gene regulon required for bacterial persistence. Characterisation of two repres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db0d9ac8-456a-519c-80fd-01c5a97b8a2e
DOI: 10.21203/rs.3.rs-2847166/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis and a novel target for enhanced TB therapyDOI 10.21203/rs.3.rs-2847166/v1Read

TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infectionSemantic proximity Read

MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infectionSemantic proximity Read

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection.Semantic proximity Read

The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis.Semantic proximity Read

The pH gradient contributes to persistence in Mycobacterium tuberculosisSemantic proximity Read

M. orygis hypervirulence provides new insights into tuberculosis pathogenesisSemantic proximity Read

Analyses of methyltransferases across the pathogenicity spectrum of different mycobacterial species point to an extremophile connectionSemantic proximity Read

Beyond antibiotic resistance: the whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteriaSemantic proximity Read

The pH gradient contributes to persistence in Mycobacterium tuberculosisSemantic proximity Read

Deciphering the transcriptomic landscape of pyrazinamide resistance in Mycobacterium tuberculosisSemantic proximity Read

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosisSemantic proximity Read

Evaluation of the role of whiB6 and kdpDE in the dominant multidrug resistant clone Mycobacterium tuberculosis B0/W148Semantic proximity Read