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Article

Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies.

Biochimie - 1 May 2024

Mishra Alok K, Thakare Ritesh P, Santani Bela G, Yabaji Shivraj M, Dixit Shivendra K, Srivastava Kishore K

Abstract excerpt

In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a formidable challenge. This adaptive ability of microorganisms to withstand drug pressure without genetic alterations further complicating global healthcare challenges. Microbial populations employ an array of persistence mechanisms, including dormancy, biofilm formation, adaptation to intracellular environments, and the...

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PMID: 38168626
DOI: 10.1016/j.biochi.2023.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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