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Article

Confinement-Induced Drug-Tolerance in Mycobacteria Mediated by an Efflux Mechanism.

PloS one - 1 Jan 2015

Luthuli Brilliant B, Purdy Georgiana E, Balagaddé Frederick K

Abstract excerpt

Tuberculosis (TB) is the world's deadliest curable disease, responsible for an estimated 1.5 million deaths annually. A considerable challenge in controlling this disease is the prolonged multidrug chemotherapy (6 to 9 months) required to overcome drug-tolerant mycobacteria that persist in human tissues, although the same drugs can sterilize genetically identical mycobacteria growing in axenic culture within...

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Identifiers

PMID: 26295942
DOI: 10.1371/journal.pone.0136231
PMCID: PMC4546595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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