Article

Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing data

2022-07-06

Abstract excerpt

In cancer, somatic mutations such as copy number alterations (CNAs) accumulate during disease progression and lead to functional intra-tumor heterogeneity that can influence the efficacy of cancer therapy. Therefore, studying the functional characteristics and spatial distribution of genetically distinct subclones is crucial to the understanding of tumor evolution and the design of cancer treatment. Here, we prese...

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Literature Corpus work: 01408a19-0fb2-5436-95e6-aaba52d3ae85
DOI: 10.1101/2022.07.05.498882

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