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Article

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity

2025-03-26

Abstract excerpt

<title>Abstract</title> <p>Chromatin remodeling complexes, such as the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, play key roles in regulating gene expression by modulating nucleosome positioning. The core subunit SMARCB1 is essential for these functions, as it anchors the complex to the nucleosome acidic patch, enabling effective chromatin remodeling. While biallelic inactivation of SMARCB1 is a hallmark...

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Literature Corpus work
c728091f-f789-5a1c-b744-36a06dde3e5c
DOI
10.21203/rs.3.rs-6018128/v1
Open publication

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