Article
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.
Cell - 27 Nov 2019
Valencia Alfredo M, Collings Clayton K, Dao Hai T, St Pierre Roodolph, Cheng Yung-Chih, Huang Junwei, Sun Zhen-Yu, Seo Hyuk-Soo, Mashtalir Nazar, Comstock Dawn E, Bolonduro Olubusayo, Vangos Nicholas E, Yeoh Zoe C, Dornon Mary Kate, Hermawan Crystal, Barrett Lee, Dhe-Paganon Sirano, Woolf Clifford J, Muir Tom W, Kadoch Cigall
Abstract excerpt
Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanistic understanding. Here, we examine the molecular, structural, and genome-wide regulatory consequences of recurrent, single-residue mutations in the putative coiled-coil...
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