Article

SMARCA4 supports the oncogenic landscape of <i>KRAS</i> -driven lung tumors

2020-04-20

Abstract excerpt

Cancer resequencing studies identify recurrent mutations in the switch/sucrose non-fermentable (SWI/SNF) complex at an unexpectedly high frequency across many cancer types. Some SWI/SNF mutations appear to be loss-of-function events, implying that the intact SWI/SNF complex is tumor suppressive. We examined the distribution and function of SMARCA4 mutations, the most frequently mutated SWI/SNF complex gene in lun...

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Literature Corpus work: 1554d0e7-336c-5e82-a2df-feb47fcef32c
DOI: 10.1101/2020.04.18.043927

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