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Article

Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments

11 Mar 2022

Abstract excerpt

Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) complex occur in 20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently mutated, and SMARCB1 loss represents a founder driver event in several malignancies, such as malignant rhabdoid tumors (MRT), epithelioid sarcoma, poorly differentiated chordoma, and renal medullary carcinoma (RMC). Intriguingly,...

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PMID: 35327458
DOI: 10.3390/biomedicines10030650

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