Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

doi:10.1016/j.celrep.2018.03.028

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Article

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

Cell reports - 3 Apr 2018

Horiuchi Keiko, Perez-Cerezales Serafín, Papasaikas Panagiotis, Ramos-Ibeas Priscila, López-Cardona Angela Patricia, Laguna-Barraza Ricardo, Fonseca Balvís Noelia, Pericuesta Eva, Fernández-González Raul, Planells Benjamín, Viera Alberto, Suja Jose Angel, Ross Pablo Juan, Alén Francisco, Orio Laura, Rodriguez de Fonseca Fernando, Pintado Belén, Valcárcel Juan, Gutiérrez-Adán Alfonso

Abstract excerpt

The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA splicing, we generated ZRSR1 mutant mice containing truncating mutations within its RNA-recognition motif. Homozygous mutant mice exhibited severe defects in erythrocytes, muscle stretch, and...

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PMID: 29617656
DOI: 10.1016/j.celrep.2018.03.028

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