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Article

Cellular differentiation state modulates the mRNA export activity of SR proteins.

The Journal of cell biology - 3 Jul 2017

Botti Valentina, McNicoll François, Steiner Michaela C, Richter Florian M, Solovyeva Anfisa, Wegener Marius, Schwich Oliver D, Poser Ina, Zarnack Kathi, Wittig Ilka, Neugebauer Karla M, Müller-McNicoll Michaela

Abstract excerpt

SR proteins function in nuclear pre-mRNA processing, mRNA export, and translation. To investigate their cellular dynamics, we developed a quantitative assay, which detects differences in nucleocytoplasmic shuttling among seven canonical SR protein family members. As expected, SRSF2 and SRSF5 shuttle poorly in HeLa cells but surprisingly display considerable shuttling in pluripotent murine P19 cells. Combining...

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Identifiers

PMID: 28592444
DOI: 10.1083/jcb.201610051
PMCID: PMC5496613

Genes

SRSF5
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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