Article

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

2022-03-06

Abstract excerpt

Alternative splicing expands the transcriptome and proteome complexity and plays essential roles in tissue development and human diseases. However, how alternative splicing regulates spermatogenesis remains largely unknown. Here, using germ cell-specific knockout mouse model, we demonstrated that the splicing factor Srsf10 is essential for spermatogenesis and male fertility. Depletion of Srsf10 in germ cells had...

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Literature Corpus work: fca70710-3ef9-52d5-9187-feeea8a49232
DOI: 10.1101/2022.03.06.483179

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