Article
Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts.
Genome research - 1 Mar 2009
Sanford Jeremy R, Wang Xin, Mort Matthew, Vanduyn Natalia, Cooper David N, Mooney Sean D, Edenberg Howard J, Liu Yunlong
Abstract excerpt
Metazoan genes are encrypted with at least two superimposed codes: the genetic code to specify the primary structure of proteins and the splicing code to expand their proteomic output via alternative splicing. Here, we define the specificity of a central regulator of pre-mRNA splicing, the conserved, essential splicing factor SFRS1. Cross-linking immunoprecipitation and high-throughput sequencing (CLIP-seq)...
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