Article

Isoform-Specific Localization Diversifies Human MSI2 Function

2026-05-18

Abstract excerpt

Musashi-2 (MSI2) is an RNA-binding protein implicated in stem cell regulation and cancer, yet reports of its regulatory activity span translational activation, repression, and effects on mRNA stability, sometimes within the same cellular context. The basis for this diversity has remained unclear. Here, we identify alternative splicing as a determinant of MSI2 regulatory activity, acting through isoform-specific su...

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Literature Corpus work: 6e59fd81-732a-5ddb-8be4-7c9edcb62966
DOI: 10.64898/2026.05.16.725683

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