Article
Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases.
BioMed research international - 1 Jan 2018
Tan Wanyan, Wang Wei, Ma Qingfeng
Abstract excerpt
Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-mediated mRNA decay. The maintenance of cellular and tissue homeostasis relies on accurate alternative splicing, and...
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