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Article

SRSF1-Regulated Alternative Splicing in Breast Cancer.

Molecular cell - 1 Oct 2015

Anczuków Olga, Akerman Martin, Cléry Antoine, Wu Jie, Shen Chen, Shirole Nitin H, Raimer Amanda, Sun Shuying, Jensen Mads A, Hua Yimin, Allain Frédéric H-T, Krainer Adrian R

Abstract excerpt

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated alternative splicing (AS) targets in organotypic three-dimensional MCF-10A cell cultures that mimic a context relevant to breast cancer. We identified and validated hundreds of endogenous SRSF1-regulated AS events. De novo discovery of the SRSF1...

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Identifiers

PMID: 26431027
DOI: 10.1016/j.molcel.2015.09.005
PMCID: PMC4597910

Genes

SRSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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