Article

Splicing factor SRSF1 acts as a novel molecular brake for CD4 T cell activation and controls key molecular pathways in SLE

2023-04-27

Abstract excerpt

T cells from systemic lupus erythematosus (SLE) patients exhibit a hyperactive phenotype with defects in homeostasis, signaling and cytokine production. We previously uncovered new roles for serine arginine-rich splicing factor 1 (SRSF1) in the control of genes involved in signaling and cytokine production in T cells. SRSF1 expression is decreased in T cells from patients with SLE and low SRSF1 levels are associat...

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Literature Corpus work: 05e7699a-2ecb-516e-bc94-01fee1cbfca2
DOI: 10.22541/au.168257725.57637198/v1

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