Article

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage

2019-11-06

Abstract excerpt

Ribosomal DNA (rDNA) is the most transcribed genomic region and contains hundreds of tandem repeats. Maintaining these rDNA repeats as well as the level of rDNA transcription is essential for cellular homeostasis. DNA damages generated in rDNA need to be efficiently and accurately repaired as rDNA repeats instability has been reported in cancer, aging and neurological diseases. Here, we describe that the histone d...

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Literature Corpus work: 84d37105-520d-523a-9a97-55f130719aea
DOI: 10.1101/833129

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