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Article

Transcription of ribosomal genes can cause nondisjunction.

The Journal of cell biology - 19 Jun 2006

Machín Felix, Torres-Rosell Jordi, De Piccoli Giacomo, Carballo Jesús A, Cha Rita S, Jarmuz Adam, Aragón Luis

Abstract excerpt

Mitotic disjunction of the repetitive ribosomal DNA (rDNA) involves specialized segregation mechanisms dependent on the conserved phosphatase Cdc14. The reason behind this requirement is unknown. We show that rDNA segregation requires Cdc14 partly because of its physical length but most importantly because a fraction of ribosomal RNA (rRNA) genes are transcribed at very high rates. We show that cells cannot...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16769819
DOI: 10.1083/jcb.200511129
PMCID: PMC2063915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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