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Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits a mouse model of DLB/PD

2021-02-19

Abstract excerpt

<title>Abstract</title> <p>ɑ-synuclein (ɑ-syn) progressively accumulates in age related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Although ɑ-syn spreading has been extensively investigated, the role of aging in the manifestation of disease remains unclear. Thus, we explored the role of aging in the pathogenesis of synucleinopathies in a mouse model of DLB/PD...

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Literature Corpus work
c71d0265-b4ec-588e-8b81-8d1e1bb2fb2e
DOI
10.21203/rs.3.rs-211252/v1
Open publication

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Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits a mouse model of DLB/PDDOI 10.21203/rs.3.rs-211252/v1
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