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Article

Inflammation drives synucleinopathy propagation

2021-08-13

Abstract excerpt

<title>Abstract</title> <p>The clinical progression of neurodegenerative diseases correlates with the spread of proteinopathy in the brain. Understanding of the mechanism of the proteinopathy spread is far from complete. Here, we propose that inflammation is fundamental to proteinopathy spread. A sequence variant of α-synuclein (V40G) was much less capable of fibril formation than wild-type α-synuclein (WT-syn) a...

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Literature Corpus work
0246a2ee-f6c9-5d50-abaa-21d4b2e233a8
DOI
10.21203/rs.3.rs-774660/v1
Open publication

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Inflammation drives synucleinopathy propagationDOI 10.21203/rs.3.rs-774660/v1
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