Article

Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic mice

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-(α)-Synuclein neuronal aggregation and loss of dopaminergic (DA) neurons. Developing animal models that replicate PD’s neuropathological phenotypes is critical for understanding its pathophysiology and evaluating potential therapeutic targets. In this study, we show that direct unilateral injection of hum...

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Literature Corpus work: 383cdc94-acb6-5fae-b0cb-309e9dbed131
DOI: 10.1101/2025.11.26.690780

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Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic miceDOI 10.1101/2025.11.26.690780Read

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