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Neurodegeneration and neuroinflammation are linked, but independent of <b>α</b> -synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s disease

2020-08-06

Abstract excerpt

A key process of neurodegeneration in Parkinson’s disease (PD) is the transneuronal spreading of α-synuclein. Alpha-synuclein is a presynaptic protein that is implicated in the pathogenesis of PD and other synucleinopathies, where it forms, upon intracellular aggregation, pathological inclusions. Other hallmarks of PD include neurodegeneration and microgliosis in susceptible brain regions. Whether it is primarily...

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Literature Corpus work
03b5856d-a813-55d4-a93d-32297dd4f7b6
DOI
10.1101/2020.08.05.237750
Open publication

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Neurodegeneration and neuroinflammation are linked, but independent of <b>α</b> -synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s diseaseDOI 10.1101/2020.08.05.237750
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