Article

Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy

2025-12-03

Abstract excerpt

<title>Abstract</title> <p>Tau pathology, characterized by the aberrant aggregation and accumulation of tau in neurons and glial cells, plays a critical role in the onset and progression of multiple neurodegenerative diseases. Although synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are primarily defined by intracytoplasmic inclusions of α-Synuclein (α-Syn), they frequently...

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Literature Corpus work: 2963afe4-f6df-5ca1-9634-b6555e51b409
DOI: 10.21203/rs.3.rs-8166445/v1

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