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Microglia Depletion Reduces Neurodegeneration and Remodels Extracellular Matrix in a Mouse Parkinson’s Disease Model Triggered by α-Synuclein Overexpression

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet whether these cells contribute to the motor deficits and neurodegeneration in PD remains poorly understood. In this study, we induced progressive dopaminergic neuron loss in mice for 8 weeks via rAAV-hSYN injection to cause the neuronal expression of α-synuclein, which produced neuroin...

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Literature Corpus work: 0e227f69-4480-589f-a196-3a0012354d8f
DOI: 10.21203/rs.3.rs-4427928/v1

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Microglia Depletion Reduces Neurodegeneration and Remodels Extracellular Matrix in a Mouse Parkinson’s Disease Model Triggered by α-Synuclein OverexpressionDOI 10.21203/rs.3.rs-4427928/v1Read

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