Article

Neurodegeneration and Neuroinflammation are Linked, but Independent of α-Synuclein Inclusions, in a Seeding/Spreading Mouse Model of Parkinson’s Disease

2020-07-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Akey process of neurodegeneration in Parkinson’s disease (PD) is the transneuronal spreading of a-synuclein. Alpha-synuclein is a presynaptic protein that is implicated in the pathogenesis of PD and other synucleinopathies, where it forms, upon intracellular aggregation, pathological inclusions.Other hallmarks of PD include neurodegeneration and microgliosis in...

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Literature Corpus work: 31585913-d8f3-5b2f-821d-81ca5c3eb8c8
DOI: 10.21203/rs.3.rs-29977/v1

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