Article

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

2020-09-26

Abstract excerpt

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy is typically detrimental to cellular fitness. To investigate how aneuploidy could contribute to tumor growth, we triggered periods of chromosomal instability (CIN) in human cells and then exposed them to a variety of different culture environments. While chromosomal instability was universally detrimental under normal growth cond...

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Literature Corpus work: c70b5d87-3434-56fe-a67e-a88b30f29ec7
DOI: 10.1101/2020.09.25.314229

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