Article

Single-chromosome aneuploidy commonly functions as a tumor suppressor

2016-02-19

Abstract excerpt

<h4>Summary</h4> Whole-chromosome aneuploidy is a hallmark of human malignancies. The prevalence of chromosome segregation errors in cancer – first noted more than 100 years ago – has led to the widespread belief that aneuploidy plays a crucial role in tumor development. Here, we set out to test this hypothesis. We transduced congenic euploid and trisomic fibroblasts with 14 different oncogenes or oncogene combin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2697d0b6-dce8-51ac-b014-8a626b6e4271
DOI: 10.1101/040162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-chromosome aneuploidy commonly functions as a tumor suppressorDOI 10.1101/040162Read

Oncogene-like addiction to aneuploidy in human cancersSemantic proximity Read

Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity Read

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cellsSemantic proximity Read

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer.Semantic proximity Read

Aneuploidy as a promoter and suppressor of malignant growth.Semantic proximity Read

Aneuploidy as a cancer vulnerabilitySemantic proximity Read

Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancerSemantic proximity Read

Selection forces underlying aneuploidy patterns in cancerSemantic proximity Read

Oncogene-like addiction to aneuploidy in human cancers.Semantic proximity Read

Aneuploidy in human cancer: new tools and perspectivesSemantic proximity Read

Losing balance: the origin and impact of aneuploidy in cancerSemantic proximity Read

Effects of aneuploidy on gene expression: implications for cancer.Semantic proximity Read