Article

Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies

2022-10-05

Abstract excerpt

Both the presence of an abnormal complement of chromosomes (aneuploidy) and an increased frequency of chromosome missegregation (chromosomal instability) are hallmarks of cancer. Analyses of cancer genome data have identified certain aneuploidy patterns in tumors; however, the bases behind their selection are largely unexplored. By establishing time-resolved long-term adaptation protocols, we found that human cell...

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Literature Corpus work: bffe5c15-75d5-5b9b-a4cf-d670239463b3
DOI: 10.1101/2022.10.04.510607

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