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Aneuploidy as a cancer vulnerability

6 Mar 2025

Abstract excerpt

Aneuploidy is prevalent in cancer and has complicated roles in tumorigenesis. Paradoxically, artificially engineered aneuploidy in normal cells reduces cellular fitness by inducing proteotoxic and genotoxic stresses. A better molecular understanding of the multifaceted roles of aneuploidy in cancer evolution offers promising avenues for future cancer therapies. Here, we discuss the patterns and consequences of...

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PMID: 40054068
DOI: 10.1016/j.ceb.2025.102490

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