Article

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

2020-06-19

Abstract excerpt

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. Here, we mapped the aneuploidy landscapes of ~1,000 human cancer cell lines and classified them by their degree of aneuploidy. Next, we performed a comprehensive analysis of large-scale genetic and chemical perturbation screens, in order to compare the cellular vulnerabilities between near-diploid and highly-aneuploid cancer cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d28bf0f9-2900-59f6-97e4-db62eba1845a
DOI: 10.1101/2020.06.18.159038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpointDOI 10.1101/2020.06.18.159038Read

Aneuploidy as a cancer vulnerabilitySemantic proximity Read

New Cell Cycle Inhibitors Target Aneuploidy in Cancer TherapySemantic proximity Read

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damageSemantic proximity Read

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy.Semantic proximity Read

On the road to cancer: aneuploidy and the mitotic checkpoint.Semantic proximity Read

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer.Semantic proximity Read

Whole genome doubling confers unique genetic vulnerabilities on tumor cellsSemantic proximity Read

Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity Read

Targeting vulnerabilities of aneuploid cells for cancer therapySemantic proximity Read

WEE1 kinase inhibition triggers severe chromosome pulverization in aneuploid cellsSemantic proximity Read

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read

Bilallelic germline mutations in <i>MAD1L1</i> induce a novel syndrome of aneuploidy with high tumor susceptibilitySemantic proximity Read