Article

Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer

2024-03-07

Abstract excerpt

Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must adapt to aneuploidy. We performed in vitro evolution of cells with extra chromosomes and obtained cell lines with improved proliferation and gene expression changes congruent with...

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Literature Corpus work: a3b119e3-8d48-5d07-8b65-839917e899bb
DOI: 10.1101/2024.03.05.583460

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