Article

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

2023-01-27

Abstract excerpt

Aneuploidy is a hallmark of human cancer, yet the cellular mechanisms that allow cells to cope with aneuploidy-induced cellular stresses remain largely unknown. Such coping mechanisms may present cellular vulnerabilities that can be harnessed for targeting cancer cells. Here, we induced aneuploidy in non-transformed RPE1-hTERT cells and derived multiple stable clones with various degrees of chromosome imbalances....

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Literature Corpus work: c0cae287-c906-5d9b-9c0d-8c473f33aef5
DOI: 10.1101/2023.01.27.525822

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